14q(II-20) |
 | snoid :
SR0000119
|
 | Length :
71 |
 | Abstract :
Homo sapiens C/D box snoRNA 14q(II-20). The cluster of the 31 highly related 14q(II) snoRNAs was discovered by a genomic analysis of the imprinted human 14q32 locus. Members of this cluster, as well as the snoRNA 14q(0) and the 9 members of the 14q(I) snoRNA cluster, are encoded in introns of the non-coding MEG8 RNA gene. Although near from the maternally expressed GTL2/MEG3 gene, the MEG8 gene is not submitted to genomic imprinting. In the human, 14q(II) is highly expressed in the brain and uterus, and to a lesser extent in the heart. Due to cross-hybridisation in Northern blot analysis, it could not be assessed if all predicted snoRNAs in this cluster are indeed expressed. These snoRNAs are not predicted to guide to 2'O-methylation of a rRNA or snRNA. |
 | GenBank accession number :
NR_003213.1 |
 | Host gene : MEG8 non-coding RNA gene |
 | Click here to see the position on the UCSC Genome Browser |
 | Target RNA : unknown |
 | References : - Cavaille, J., Seitz, H., Paulsen, M., Ferguson-Smith, A. C., and Bachellerie, J. P. (2002). Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. Hum Mol Genet, 11, 1527-1538.
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 | Sequence :
|
snoRNABase - http://www-snorna.biotoul.fr/ |
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