|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SCARNA16||small Cajal body-specific RNA 16|
Homo sapiens ACA47 scaRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U5 of the U1 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Reddy et al. (1981). As other modification guides of RNA pol II-transcribed spliceosomal snRNAs, ACA47 presumably resides in Cajal bodies. In agreement, a conserved CAB box (Richard et al., 2003 ) is present in the 3' loop.
In mammals, the ACA47 host gene is protein non-coding. The most likely ACA47 in fugu, tetraodon, stickleback and medaka resides in the PDHA1 gene.
|GenBank accession number :
|Host gene : Cluster of mRNAs/ESTs (Unigene Hs.398102).|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : U1 snRNA U5|
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Richard, P., Darzacq, X., Bertrand, E., Jady, B. E., Verheggen, C., and Kiss, T. (2003). A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. Embo J, 22, 4283-4293.
- Reddy, R., Henning, D., and Busch, H. (1981a). Pseudouridine residues in the 5'-terminus of uridine-rich nuclear RNA I (U1 RNA). Biochem Biophys Res Commun, 98, 1076-1083.
|snoRNABase - http://www-snorna.biotoul.fr/|