|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SCARNA18||small Cajal body-specific RNA 18|
Homo sapiens U109 scaRNA.
This H/ACA box RNA was cloned by Gu et al. (2005) from blood cells by an RT-PCR method that preferentially amplifies H/ACA box snoRNAs. Its expression was evidenced by Northern blot. U109 is predicted to guide the pseudouridylation of residue U6 of the U1 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Reddy et al. (1981).
As other modification guides of RNA pol II-transcribed spliceosomal snRNAs, U109 presumably resides in Cajal bodies. In agreement, the conserved CAB box (Richard et al., 2003) resides in the loop of the 3’ stem.
|GenBank accession number :
|Host gene : MGC23909 (hypothetical protein LOC153339)|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : U1 snRNA U6|
- Gu, A. D., Zhou, H., Yu, C. H., and Qu, L. H. (2005). A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes. Nucleic Acids Res 33, e194.
- Reddy, R., Henning, D., and Busch, H. (1981a). Pseudouridine residues in the 5'-terminus of uridine-rich nuclear RNA I (U1 RNA). Biochem Biophys Res Commun, 98, 1076-1083.
- Richard, P., Darzacq, X., Bertrand, E., Jady, B. E., Verheggen, C., and Kiss, T. (2003). A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. Embo J, 22, 4283-4293.
|snoRNABase - http://www-snorna.biotoul.fr/|