|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SCARNA13||small Cajal body-specific RNA 13|
Homo sapiens U93 scaRNA.
This RNA was cloned by Kiss et al. (2002) from HeLa cells. It contains two tandemly arranged box H/ACA domains. FISH experiments showed that U93 co-localizes with coilin in Cajal bodies. U93 is predicted to guide the pseudouridylation of U54 of the U2 spliceosomal snRNA and U53 of snRNA U5 (Kiss et al., 2002; Schattner et al., 2006). The modification of these residues was experimentally established (Shibata et al., 1975; Reddy, 1988).|
|GenBank accession number :
|Host gene : Cluster of ESTs (Unigene Hs.448753).|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : U2 snRNA U54 and U5 snRNA U53|
- Kiss, A. M., Jady, B. E., Darzacq, X., Verheggen, C., Bertrand, E., and Kiss, T. (2002). A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains. Nucleic Acids Res 30, 4643-4649.
- Shibata, H., Ro-Choi, T. S., Reddy, R., Choi, Y. C., Henning, D., and Busch, H. (1975). The primary nucleotide sequence of nuclear U-2 ribonucleic acid. The 5'-terminal portion of the molecule. J Biol Chem, 250, 3909-3920.
- Schattner, P., Barberan-Soler, S., and Lowe, T. M. (2006). A computational screen for mammalian pseudouridylation guide H/ACA RNAs. Rna 12, 15-25
- Reddy R (1988) Compilation of small RNA sequences. Nuc. Acids Res 16 Suppl: r71-85
|snoRNABase - http://www-snorna.biotoul.fr/|