|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SNORA57||small nucleolar RNA, H/ACA box 57|
Homo sapiens U99 snoRNA.
This H/ACA box RNA was originally cloned from a mouse brain library by Huttenhofer et al. (2001) and named MBII-104. The human orthologue was named U99 by Vitali et al. (2003) and found to be enriched in the nucleolar fraction of HeLa cells. This snoRNA is predicted to guide the pseudouridylation of 18S rRNA U1004 (Schattner et al., 2006). Maden and Wakeman (1988) could not determine whether U1003 or U1004 was modified.
U99 is hosted by the LOC751071 gene, that encodes a predicted protein well conserved in marmoset, cow, dog, opossum (XP_001362339)and xenopus tropicalis (EST CX918306). However, the mouse and rat orthologous genes are predicted to encode unrelated proteins (mouse mRNA AK011444).
In lizard, a U99 copy resides in the GNAI1 gene. In fugu, tetraodon, stickleback and medaka, U99 resides, as U20, U23 and U82, in the nucleolin (NCL) gene (one intragenic duplication in stickleback). In zebrafish, one U99 copy resides in the SIAHBP1 gene, and a second one near the GANAB gene (as in the human genome).
|GenBank accession number :
|Host gene : LOC751071|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : 18S rRNA U1004|
|sno/scaRNAs with same target 18S rRNA U1004 : ACA60  |
- Vitali, P., Royo, H., Seitz, H., Bachellerie, J. P., Huttenhofer, A., and Cavaille, J. (2003). Identification of 13 novel human modification guide RNAs. Nucleic Acids Res 31, 6543-6551.
- Huttenhofer, A., Kiefmann, M., Meier-Ewert, S., O'Brien, J., Lehrach, H., Bachellerie, J. P., and Brosius, J. (2001). RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Embo J 20, 2943-2953.
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.
- Schattner, P., Barberan-Soler, S., and Lowe, T. M. (2006). A computational screen for mammalian pseudouridylation guide H/ACA RNAs. Rna 12, 15-25
|snoRNABase - http://www-snorna.biotoul.fr/|