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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA20small Cajal body-specific RNA 20
snoid : SR0000247
Length : 140
Abstract : Homo sapiens ACA66 scaRNA. This H/ACA box RNA was characterized by bioinformatics, and its expression verified by Northern blot and primer extension in mouse (Schattner et al., 2006). It is predicted to guide the pseudouridylation of U12 snRNA U28. The pseudouridylation of this nucleotide was experimentally demonstrated by Massenet et al. (2002). Schattner et al. (2006) noted that human and mouse ACA66 are hosted in introns of non orthologous genes (USP32 and Wbscr22, respectively). As other modification guides of snRNAs transcribed by RNA polII, ACA66 is predicted to reside in Cajal bodies.
GenBank accession number :
Host gene : USP32 (ubiquitin specific protease 32)
Click here to see the position on the UCSC Genome Browser
Target RNA : U12 snRNA U28
References :
- Massenet, S., Mougin, A. and Branlant, C. (1998) Posttranscriptional modification in the U small nuclear RNAs, p.201-227. In H. Grosjean and R. Benne (ed.), Modification and editing of RNA. ASM Press, Washington D.C.
- Schattner, P., Barberan-Soler, S., and Lowe, T. M. (2006). A computational screen for mammalian pseudouridylation guide H/ACA RNAs. Rna 12, 15-25
Sequence :
Phylogenic conservation: Alignment - Fasta file
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