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14q(I-6)
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORD113-6small nucleolar RNA, C/D box 113-6
snoid : SR0000096
Length : 74
Abstract : Homo sapiens C/D box snoRNA 14q(I-6). The cluster of the 9 highly related 14q(I) snoRNAs was discovered by a genomic analysis of the imprinted human 14q32 locus. Members of this cluster, as well as the snoRNA 14q(0) and the 31 members of the 14q(II) snoRNA cluster, are encoded in introns of the non-coding MEG8 RNA gene. Although near from the maternally expressed GTL2/MEG3 gene, the MEG8 gene is not submitted to genomic imprinting. In the human, 14q(I) is highly expressed in the brain and uterus, and to a lesser extent in the heart. Due to cross-hybridisation in Northern blot analysis, it could not be assessed if all predicted snoRNAs in this cluster are indeed expressed. These snoRNAs are not predicted to guide to 2'O-methylation of a rRNA or snRNA.
GenBank accession number : NR_003234.1
Host gene : MEG8 non-coding RNA gene
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Target RNA : unknown
References :
- Cavaille, J., Seitz, H., Paulsen, M., Ferguson-Smith, A. C., and Bachellerie, J. P. (2002). Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region. Hum Mol Genet, 11, 1527-1538.
Sequence :
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