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ACA14a
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA14Asmall nucleolar RNA, H/ACA box 14A
snoid : SR0000351
Length : 134
Abstract : Homo sapiens ACA14a snoRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. As its close paralogue ACA14b, it is predicted to guide the pseudouridylation of residue U966 of 18S rRNA. Maden and Wakeman (1988) could not determine whether U966, U968 or U969 was modified. The pseudouridylation of residue U966 was experimentally confirmed by primer extension mapping by Kiss et al. (2004).
GenBank accession number : AJ609456
Host gene : hypothetical protein FLJ26468 fis (alternative form of NADPH-cytochrome P450 reductase (EC 1.6.2.4) mRNA).
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Target RNA : 18S rRNA U966
sno/scaRNAs with same target 18S rRNA U966 : ACA14b   
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.
Sequence :
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