Homo sapiens ACA26 scaRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues U39 and U41 of the U2 spliceosomal snRNA. The pseudouridylation of these residues was previously reported by Shibata et al. (1975). As other modification guides of RNA pol II-transcribed spliceosomal snRNAs, ACA26 co-localizes with coilin in Cajal bodies after overexpression in HeLa cells. ACA26 and ACA42 share the same host gene.