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ACA26
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA4small Cajal body-specific RNA 4
snoid : SR0000025
Length : 129
Abstract : Homo sapiens ACA26 scaRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues U39 and U41 of the U2 spliceosomal snRNA. The pseudouridylation of these residues was previously reported by Shibata et al. (1975). As other modification guides of RNA pol II-transcribed spliceosomal snRNAs, ACA26 co-localizes with coilin in Cajal bodies after overexpression in HeLa cells. ACA26 and ACA42 share the same host gene.
GenBank accession number : AJ609483
Host gene : KIAA0907 (hypothetical protein, 614aa).
Click here to see the position on the UCSC Genome Browser
Target RNA : U2 snRNA U41 and U2 snRNA U39
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Shibata, H., Ro-Choi, T. S., Reddy, R., Choi, Y. C., Henning, D., and Busch, H. (1975). The primary nucleotide sequence of nuclear U-2 ribonucleic acid. The 5'-terminal portion of the molecule. J Biol Chem, 250, 3909-3920.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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