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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA8small nucleolar RNA, H/ACA box 8
snoid : SR0000069
Length : 139
Abstract : Homo sapiens ACA8 snoRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues U1056 and U1081 of 18S rRNA. The pseudouridylation of these residues was previously reported by Maden and Wakeman (1988). Schattner et al. (2006) predicted that ACA8 can also guide the pseudouridylation of 28S rRNA U3832 (as snoRNA E2). ACA1, ACA8, ACA18, ACA25, ACA32 and ACA40 and the C/D box snoRNAs mgh28S-2409 and mgh28S-2411 share the same host gene (MGC5306).
GenBank accession number :
Host gene : MGC5306 (hypothetical protein FLJ23363, 278aa).
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Target RNA : 18S rRNA U1056 and 18S rRNA U1081 and 28S rRNA U3832
sno/scaRNAs with same target 28S rRNA U3832 : E2   
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.
- Schattner, P., Barberan-Soler, S., and Lowe, T. M. (2006). A computational screen for mammalian pseudouridylation guide H/ACA RNAs. Rna 12, 15-25
Sequence :
Phylogenic conservation: Alignment - Fasta file
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