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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORD64small nucleolar RNA, C/D box 64
snoid : SR0000133
Length : 67
Abstract : Homo sapiens C/D box snoRNA HBII-13: this snoRNA was first cloned in the mouse by Cavaillé et al. (2000), and found to be brain-specific. HBII-13 is predominantly expressed in the brain, and, to a lesser extent, in muscle, lung and kidney. As HBII-85 and HBII-52, HBI-13 was not expressed in the brain of a patient with a paternal 15q11-q13 deletion (Prader-Willi syndrome), but was normally expressed when the deletion is maternally inherited (Angelman syndrome). HBII-13 (as well as HBII-436, HBII-437, HBII-438A/B and the two clusters of HBII-85, HBII-52 snoRNAs) is encoded in an intron of the large (460kb), paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS), that is antisense to the maternally expressed UBE3A gene (Runt et al., 2001). This snoRNA has no identified RNA target.
GenBank accession number : NR_001294
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Target RNA : unknown
References :
- Runte, M., Huttenhofer, A., Gross, S., Kiefmann, M., Horsthemke, B., and Buiting, K. (2001). The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. Hum Mol Genet, 10, 2687-2700.
- Cavaille, J., Buiting, K., Kiefmann, M., Lalande, M., Brannan, C. I., Horsthemke, B., Bachellerie, J. P., Brosius, J., and Huttenhofer, A. (2000). Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. Proc Natl Acad Sci U S A, 97, 14311-14316.
Sequence :
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