Abstract :
Homo sapiens C/D box snoRNA HBII-438A. This snoRNA was discovered by computer aided search of conserved sequences and structural motifs in the Prader-Willi locus (15q11-q13). It is expressed in brain and kidney, and, to a lesser extent, lung, and muscle. It is not expressed in the brain of a Prader-Willi syndrome patient, but in the brain from an Angelman syndrome patient, showing its expression from the paternal allele only. HBII-438A (as well as HBII-438B (a perfect copy of HBII-438A), HBII-13, HBII-437, HBII-436 and the two clusters of HBII-85 and HBII-52 snoRNAs) is encoded in an intron of the large (460kb), paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS), that is antisense to the maternally expressed UBE3A gene. This snoRNA has no identified RNA target.
