Homo sapiens C/D box snoRNA U25. This snoRNA was initially characterized as a conserved intronic sequence in the U22 host gene, UHG. Other introns of the same gene host the C/D box snoRNAs U26-U31 (Tycowski, Shu and Steitz, 1996). U25 was postulated to guide the 2'O-ribose methylation of 18S rRNA G1490 by Kiss-Laszlo et al. (1996). This was experimentally verifed in Xenopus oocytes by Tycowski et al. (1996).
GenBank accession number :
Host gene : U22 host gene (UHG)
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