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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORD25small nucleolar RNA, C/D box 25
snoid : SR0000061
Length : 67
Abstract : Homo sapiens C/D box snoRNA U25. This snoRNA was initially characterized as a conserved intronic sequence in the U22 host gene, UHG. Other introns of the same gene host the C/D box snoRNAs U26-U31 (Tycowski, Shu and Steitz, 1996). U25 was postulated to guide the 2'O-ribose methylation of 18S rRNA G1490 by Kiss-Laszlo et al. (1996). This was experimentally verifed in Xenopus oocytes by Tycowski et al. (1996).
GenBank accession number :
Host gene : U22 host gene (UHG)
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Target RNA : 18S rRNA G1490
References :
- Kiss-Laszlo, Z., Henry, Y., Bachellerie, J. P., Caizergues-Ferrer, M., and Kiss, T. (1996). Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell, 85, 1077-1088.
- Tycowski, K. T., Shu, M. D., and Steitz, J. A. (1996). A mammalian gene with introns instead of exons generating stable RNA products. Nature, 379, 464-466.
- Tycowski, K. T., Smith, C. M., Shu, M. D., and Steitz, J. A. (1996). A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus. Proc Natl Acad Sci U S A, 93, 14480-14485.
Sequence :
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