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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORD50Asmall nucleolar RNA, C/D box 50A
snoid : SR0000337
Length : 74
Abstract : Homo sapiens C/D box snoRNA U50. This snoRNA was cloned by Kiss-Laszlo et al. (1996), and predicted to guide the 2'O-ribose methylation of both 28S rRNA C2848 and G2863, although the latter was not mapped by Maden (1990). A closely related copy, U50B, with mutations in both anti-sense guiding sequences, resides in the same host gene. A t(3;6)(q27;q15) translocation found in a patient with B-cell lymphoma fuses the 5' part of the BCL6 gene to the 3' part of the U50/U50B host gene (Tanaka et al., 2000). U50 acts as a tumor-suppressor in prostate cancer cells. A 2-bp homozygous deletion in the U50 sequence is associated with clinically significant prostate cancer (Dong et al., 2008).
GenBank accession number : X96662
Host gene : Cluster of mRNAs/ESTs (Unigene Hs.292457)
Click here to see the position on the UCSC Genome Browser
Target RNA : 28S rRNA C2848 and 28S rRNA G2863
References :
- Kiss-Laszlo, Z., Henry, Y., Bachellerie, J. P., Caizergues-Ferrer, M., and Kiss, T. (1996). Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell, 85, 1077-1088.
- Dong, X. Y., Rodriguez, C., Guo, P., Sun, X., Talbot, J. T., Zhou, W., Petros, J., Li, Q., Vessella, R. L., Kibel, A. S., et al. (2008). SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer. Hum Mol Genet 17, 1031-1042.
- Tanaka, R., Satoh, H., Moriyama, M., Satoh, K., Morishita, Y., Yoshida, S., Watanabe, T., Nakamura, Y., and Mori, S. (2000). Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma. Genes Cells 5, 277-287
Sequence :
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