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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA64small nucleolar RNA, H/ACA box 64
snoid : SR0000217
Length : 134
Abstract : Homo sapiens U64 snoRNA. This H/ACA box RNA was cloned from a HeLa cells by Ganot et al. (1997b). Its role in guiding pseudouridylation of U4975 in 28S rRNA was evidenced by Ganot et al. (1997a). The pseudouridylation of this residue was previously reported by Ofengand and Bakin (1997). U64 and ACA10 share the same host gene. The NMR stucture of U64 3' loop was determined by Theimer et al. (2007) and compared to the CAB-containing loop of hTR and U85 scaRNAs.
GenBank accession number : Y11158
Host gene : RPS2 (ribosomal protein S2)
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Target RNA : 28S rRNA U4975
sno/scaRNAs with same target 28S rRNA U4975 : ACA22   
References :
- Ganot, P., Bortolin, M. L., and Kiss, T. (1997a). Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell 89, 799-809.
- Ofengand, J., and Bakin, A. (1997). Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts. J Mol Biol 266, 246-268.
- Ganot, P., Caizergues-Ferrer, M., and Kiss, T. (1997b). The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Genes Dev 11, 941-956.
- Theimer, C. A., Jady, B. E., Chim, N., Richard, P., Breece, K. E., Kiss, T., and Feigon, J. (2007). Structural and functional characterization of human telomerase RNA processing and cajal body localization signals. Mol Cell 27, 869-881
Sequence :
Phylogenic conservation: Alignment - Fasta file
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