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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA65small nucleolar RNA, H/ACA box 65
snoid : SR0000358
Length : 137
Abstract : Homo sapiens U65 snoRNA. This H/ACA box RNA was cloned from HeLa cells by Ganot et al. (1997b). Its role in guiding the pseudouridylation of residues U4373 and U4427 of 28S rRNA was evidenced by Ganot et al. (1997a). The pseudouridylation of these residues was previously reported by Ofengand and Bakin (1997). Note that the published sequence differs from the genomic sequence by 1nt. The NMR structure of the 3' stem-loop with a substrate RNA molecule was determined by Wu et Feigon (2007) and confirms the predicted model shown below. However, the NMR structure of the 5' stem-loop with target RNA determined by Jin et al. (2007) slightly differs from the model.
GenBank accession number : Y11159
Host gene : RPL12 (ribosomal protein L12)
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Target RNA : 28S rRNA U4373 and 28S rRNA U4427
References :
- Ganot, P., Bortolin, M. L., and Kiss, T. (1997a). Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell 89, 799-809.
- Ofengand, J., and Bakin, A. (1997). Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts. J Mol Biol 266, 246-268.
- Ganot, P., Caizergues-Ferrer, M., and Kiss, T. (1997b). The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Genes Dev 11, 941-956.
- Jin, H., Loria, J. P., and Moore, P. B. (2007). Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA. Mol Cell 26, 205-215
- Wu, H., and Feigon, J. (2007). H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification. Proc Natl Acad Sci U S A 104, 6655-6660
Sequence :
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