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U66
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA66small nucleolar RNA, H/ACA box 66
snoid : SR0000021
Length : 133
Abstract : Homo sapiens U66 snoRNA. This H/ACA box RNA was cloned from HeLa cells by Ganot et al. (1997b). Its role in guiding pseudouridylation of U119 in 18S rRNA was evidenced by Ganot et al. (1997a). The pseudouridylation of this residue was previously reported by Maden and Wakeman (1988). The published sequence differs from the genomic sequence by 1nt. U66 and the C/D box snoRNA U21 share the same host gene (RPL5). Two copies of U66 reside in rat and mouse Rpl5 gene. In chicken and xenopus, U66 is hosted by the Zrf gene.
GenBank accession number : Y11160
Host gene : RPL5 (ribosomal protein L5)
Click here to see the position on the UCSC Genome Browser
Target RNA : 18S rRNA U119
References :
- Ganot, P., Bortolin, M. L., and Kiss, T. (1997a). Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell 89, 799-809.
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.
- Ganot, P., Caizergues-Ferrer, M., and Kiss, T. (1997b). The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Genes Dev 11, 941-956.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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