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mgU2-19/30  also known as Z32
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA9small Cajal body-specific RNA 9
snoid : SR0000064
Length : 353
Abstract : Homo sapiens mgU2-19/30 scaRNA. This scaRNA was characterized by Tycowski et al. (2004). It is composed of two C/D box domains that are predicted to guide the 2'O-ribose methylation of U2 snRNA G19 and A30. Northern blot analysis of RNAs form HeLa cells revealed the presence of the full length mgU2-19/30, as well as the separate parts mgU2-19 and mgU2-30. The latter was independently cloned by H. Zhou and L.-H. Qu as Z32 snoRNA (AJ009638). Cell fractionation experiments revealed the presence of mgU2-19/30 in the nucleoplasm, in agreement with a localization in Cajal bodies as other modification guides for RNA polII transcribed snRNAs (Darzacq et al., 2002). However, mgU2-19 and mgU2-30 resided in the nucleolar fraction.
GenBank accession number : BK005567
Host gene : AB051518 (KIAA1731protein, 2056aa
Click here to see the position on the UCSC Genome Browser
Target RNA : U2 snRNA G19 and U2 snRNA A30
References :
- Darzacq, X., Jady, B. E., Verheggen, C., Kiss, A. M., Bertrand, E., and Kiss, T. (2002). Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. Embo J 21, 2746-2756.
- Tycowski, K. T., Aab, A., and Steitz, J. A. (2004). Guide RNAs with 5' Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa. Curr Biol, 14, 1985-1995.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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