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mgU2-25/61
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA2small Cajal body-specific RNA 2
snoid : SR0000022
Length : 420
Abstract : Homo sapiens mgU2-25/61 scaRNA. This scaRNA was characterized by Tycowski et al. (2004). It is composed of two C/D box domains that are predicted to guide the 2'O-ribose methylation of U2 snRNA G25 and C61. Northern blot analysis of RNAs form HeLa cells revealed the presence of the full length mgU2-25/61, as well as its 3' C/D box domain, that corresponds to HBII-382, the human orthologue of the mouse MBII-382 cloned by Hüttenhoffer et al. (2001). Cell fractionation experiments localized mgU2-25/61 in the nucleoplamic fraction (in agreement with a localization in Cajal bodies), but HBII-382 in the nucleolar fraction. From its genomic localization, mgU2-25/61 is transcribed from an independent unit. In agreement, a significant fraction bears a trimethylguanosine cap.
GenBank accession number :
Host gene : Independent transcriptional unit
Click here to see the position on the UCSC Genome Browser
Target RNA : U2 snRNA G25 and U2 snRNA C61
sno/scaRNAs with same target U2 snRNA C61 : HBII-382   
References :
- Huttenhofer, A., Kiefmann, M., Meier-Ewert, S., O'Brien, J., Lehrach, H., Bachellerie, J. P., and Brosius, J. (2001). RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Embo J 20, 2943-2953.
- Tycowski, K. T., Aab, A., and Steitz, J. A. (2004). Guide RNAs with 5' Caps and Novel Box C/D snoRNA-like Domains for Modification of snRNAs in Metazoa. Curr Biol, 14, 1985-1995.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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