|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SCARNA12||small Cajal body-specific RNA 12|
Homo sapiens U89 scaRNA
This RNA was cloned by Darzacq et al. (2002) from HeLa cells. It is composed of an H/ACA box domain and a C/D box domain, and is associated with both fibrillarin and Gar1p. U89 co-localizes with coilin in Cajal bodies, and is predicted to guide the pseudouridylation of residue U46 in U5 snRNA (as U85). The modification of this residue was experimentally established by Krol et al. (1981).|
|GenBank accession number :
|Host gene : REA (B-cell receptor associated protein, D-prohibitin).|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : U5 snRNA U46|
|sno/scaRNAs with same target U5 snRNA U46 : U85  |
- Darzacq, X., Jady, B. E., Verheggen, C., Kiss, A. M., Bertrand, E., and Kiss, T. (2002). Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. Embo J 21, 2746-2756.
- Krol, A., Gallinaro, H., Lazar, E., Jacob, M., and Branlant, C. (1981). The nuclear 5S RNAs from chicken, rat and man. U5 RNAs are encoded by multiple genes. Nucleic Acids Res, 9, 769-787.
|snoRNABase - http://www-snorna.biotoul.fr/|