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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA10small Cajal body-specific RNA 10
snoid : SR0000073
Length : 330
Abstract : Homo sapiens U85 scaRNA. This RNA was cloned by Jády and Kiss (2001) from HeLa cells. It is composed of an H/ACA box domain and a C/D box domain, and is associated with both fibrillarin and Gar1p. It guides both the 2'-O-ribose methylation of the C45 residue of the U5 spliceosomal snRNA, and the pseudouridylation of the neighbouring U46 residue. U85 was subsequently shown to co-localize with coilin in Cajal bodies (Darzacq et al., 2002). Mutagenesis studies showed that U85 contains two copies of the Cajal body-specific localization signal, or CAB box (agAG), common to scaRNAs (Richard et al., 2003). The NMR structure of the U85 5' CAB box was determined by Theimer et al. (2007).
GenBank accession number : AF308283
Host gene : CNAP1 (Condensin subunit 1, Chromosome condensation-related SMC-associated protein 1, Chromosome-associated protein D2)
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Target RNA : U5 snRNA U46 and U5 snRNA C45
sno/scaRNAs with same target U5 snRNA U46 : U89   
References :
- Darzacq, X., Jady, B. E., Verheggen, C., Kiss, A. M., Bertrand, E., and Kiss, T. (2002). Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. Embo J 21, 2746-2756.
- Jady, B. E., and Kiss, T. (2001). A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA. Embo J 20, 541-551.
- Richard, P., Darzacq, X., Bertrand, E., Jady, B. E., Verheggen, C., and Kiss, T. (2003). A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. Embo J, 22, 4283-4293.
- Theimer, C. A., Jady, B. E., Chim, N., Richard, P., Breece, K. E., Kiss, T., and Feigon, J. (2007). Structural and functional characterization of human telomerase RNA processing and cajal body localization signals. Mol Cell 27, 869-881
Sequence :
Phylogenic conservation: Alignment - Fasta file
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