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| Result of your query |
| U85 | |||||||
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| snoid : SR0000073 | ||||||
| Length : 330 | ||||||
| Abstract : Homo sapiens U85 scaRNA. This RNA was cloned by Jády and Kiss (2001) from HeLa cells. It is composed of an H/ACA box domain and a C/D box domain, and is associated with both fibrillarin and Gar1p. It guides both the 2'-O-ribose methylation of the C45 residue of the U5 spliceosomal snRNA, and the pseudouridylation of the neighbouring U46 residue. U85 was subsequently shown to co-localize with coilin in Cajal bodies (Darzacq et al., 2002). Mutagenesis studies showed that U85 contains two copies of the Cajal body-specific localization signal, or CAB box (agAG), common to scaRNAs (Richard et al., 2003). The NMR structure of the U85 5' CAB box was determined by Theimer et al. (2007). | ||||||
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| GenBank accession number : AF308283 | ||||||
| Host gene : CNAP1 (Condensin subunit 1, Chromosome condensation-related SMC-associated protein 1, Chromosome-associated protein D2) | ||||||
| Click here to see the position on the UCSC Genome Browser | ||||||
| Target RNA : U5 snRNA U46 and U5 snRNA C45 | ||||||
| sno/scaRNAs with same target U5 snRNA U46 : U89 | ||||||
| References : - Darzacq, X., Jady, B. E., Verheggen, C., Kiss, A. M., Bertrand, E., and Kiss, T. (2002). Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. Embo J 21, 2746-2756. - Jady, B. E., and Kiss, T. (2001). A small nucleolar guide RNA functions both in 2'-O-ribose methylation and pseudouridylation of the U5 spliceosomal RNA. Embo J 20, 541-551. - Richard, P., Darzacq, X., Bertrand, E., Jady, B. E., Verheggen, C., and Kiss, T. (2003). A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. Embo J, 22, 4283-4293. - Theimer, C. A., Jady, B. E., Chim, N., Richard, P., Breece, K. E., Kiss, T., and Feigon, J. (2007). Structural and functional characterization of human telomerase RNA processing and cajal body localization signals. Mol Cell 27, 869-881 | ||||||
| Sequence : | ||||||
| Phylogenic conservation: Alignment - Fasta file | ||||||
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