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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA18small Cajal body-specific RNA 18
snoid : SR0000324
Length : 133
Abstract : Homo sapiens U109 scaRNA. This H/ACA box RNA was cloned by Gu et al. (2005) from blood cells by an RT-PCR method that preferentially amplifies H/ACA box snoRNAs. Its expression was evidenced by Northern blot. U109 is predicted to guide the pseudouridylation of residue U6 of the U1 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Reddy et al. (1981). As other modification guides of RNA pol II-transcribed spliceosomal snRNAs, U109 presumably resides in Cajal bodies. In agreement, the conserved CAB box (Richard et al., 2003) resides in the loop of the 3 stem.
GenBank accession number : AM055742
Host gene : MGC23909 (hypothetical protein LOC153339)
Click here to see the position on the UCSC Genome Browser
Target RNA : U1 snRNA U6
References :
- Gu, A. D., Zhou, H., Yu, C. H., and Qu, L. H. (2005). A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes. Nucleic Acids Res 33, e194.
- Reddy, R., Henning, D., and Busch, H. (1981a). Pseudouridine residues in the 5'-terminus of uridine-rich nuclear RNA I (U1 RNA). Biochem Biophys Res Commun, 98, 1076-1083.
- Richard, P., Darzacq, X., Bertrand, E., Jady, B. E., Verheggen, C., and Kiss, T. (2003). A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. Embo J, 22, 4283-4293.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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