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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORA10small nucleolar RNA, H/ACA box 10
snoid : SR0000216
Length : 133
Abstract : Homo sapiens ACA10 snoRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U4491 of 28S rRNA and of residue U210 of 18S rRNA. The pseudouridylation of 28S U4491 was previously reported by Ofengand and Bakin (1997). The pseudouridylation of U210 in 18S rRNA was experimentally confirmed by primer extension mapping by Kiss et al. (2004). ACA10 and U64 share the same host gene. In the mouse RPS2 gene, the ACA10 sequence is interrupted by a B1 element (marked by // in the Alignment file). ACA10 could not be localized in rat and opossum RPS2 genes.
GenBank accession number : AJ609432
Host gene : RPS2 (ribosomal protein S2)
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Target RNA : 18S rRNA U210 and 28S rRNA U4491
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Ofengand, J., and Bakin, A. (1997). Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts. J Mol Biol 266, 246-268.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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