Abstract :
Homo sapiens ACA10 snoRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U4491 of 28S rRNA and of residue U210 of 18S rRNA. The pseudouridylation of 28S U4491 was previously reported by Ofengand and Bakin (1997). The pseudouridylation of U210 in 18S rRNA was experimentally confirmed by primer extension mapping by Kiss et al. (2004). ACA10 and U64 share the same host gene.
In the mouse RPS2 gene, the ACA10 sequence is interrupted by a B1 element (marked by // in the Alignment file). ACA10 could not be localized in rat and opossum RPS2 genes.
