Homo sapiens ACA35 scaRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U89 of the U2 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Shibata et al. (1975). As other modification guides of RNA polII-transcribed spliceosomal RNAs, ACA35 co-localizes with coilin in Cajal bodies after overexpression in HeLa cells.