Homo sapiens ACA37 snoRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U4643 of 28S rRNA. The pseudouridylation of this residue was previously reported by Ofengand and Bakin (1997).
ACA37 is a Type 1 snoRT originating from ACA30, or more likely from an ACA30 paralogue, ACA30b, hosted by the KIAA1797 gene (Weber, 2006). This snoRT is present in human, chimp, orangutan, rhesus and marmoset genomes, but is absent from bushbaby genome.