Homo sapiens ACA41 snoRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U1643 of 18S rRNA. The pseudouridylation of this residue was previously reported by Maden and Wakeman (1988).
The mouse ortholog, MBI-83, was cloned by Huttenhofer et al. 2001).
A primate-specific type 2 ACA41 snoRT (also present in marmoset) resides in the C15orf21 gene (sense orientation; chr15:43,616,740-43,616,867; hg18) (Luo and Li, 2007; Weber, unpublished).