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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA11small Cajal body-specific RNA 11
snoid : SR0000074
Length : 137
Abstract : Homo sapiens ACA57 scaRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U43 of the U5 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Krol et al. (1981). As other modification guides of RNA polII-transcribed spliceosomal RNAs, ACA57 co-localizes with coilin in Cajal bodies after overexpression in HeLa cells.
GenBank accession number : AJ609487
Host gene : CHD4 (Similar to chromodomain helicase DNA binding protein 4).
Click here to see the position on the UCSC Genome Browser
Target RNA : U5 snRNA U43
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Krol, A., Gallinaro, H., Lazar, E., Jacob, M., and Branlant, C. (1981). The nuclear 5S RNAs from chicken, rat and man. U5 RNAs are encoded by multiple genes. Nucleic Acids Res, 9, 769-787.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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