Homo sapiens ACA57 scaRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U43 of the U5 spliceosomal snRNA. The pseudouridylation of this residue was previously reported by Krol et al. (1981). As other modification guides of RNA polII-transcribed spliceosomal RNAs, ACA57 co-localizes with coilin in Cajal bodies after overexpression in HeLa cells.