Homo sapiens ACA67 snoRNA. This H/ACA box RNA was characterized by bioinformatics, and its expression verified by Northern blot and primer extension in mouse (Schattner et al., 2006). As ACA42, ACA67 is predicted to guide the pseudouridylation of 18s rRNA U109 and U572.
ACA67 is a primate-specific Type 1 snoRT (present in human, chimp, orangutan, rhesus, marmoset, not treeshrew), whose parental copy, ACA67B, resides in the ODC1 gene (Weber, 2006). A second primate-specific Type 1 ACA67B snoRTs resides in the JTV1 gene (chr7:6,023,034-6,023,168). A third one (extragenic, chr16:30,338,447-30,338,581) is embedded in a complex array of Alu elements. ACA42 might be an old ACA67B snoRT.
A rodent-specific snoRT resides in the RPL6 gene, and a cow-specific one in the EIF2A gene.
GenBank accession number :
Host gene : C21orf108 mRNA
Click here to see the position on the UCSC Genome Browser
Target RNA : 18S rRNA U109 and 18S rRNA U572
sno/scaRNAs with same target 18S rRNA U109 :ACA42  ACA67B
sno/scaRNAs with same target 18S rRNA U572 :ACA42  ACA67B