Abstract :
Homo sapiens C/D box snoRNA HBII-436. This snoRNA was discovered by computer aided search of conserved sequences and structural motifs near the SNURF-SNRPN gene in the Prader-Willi locus (15q11-q13). It is expressed in brain, kidney, lung, and, to a lesser extent, heart, muscle and liver. It is not expressed in the brain of a Prader-Willi syndrome patient, but in the brain from an Angelman syndrome patient, showing its expression from the paternal allele only. HBII-436 ( as HBII-437, HBII-438A/B and the two clusters of HBII-52 and HBII-85 snoRNAs) is encoded in an intron of the large (460kb), paternally expressed, transcription unit (SNURF-SNRNP-UBE3A AS), that is antisense to the maternally expressed UBE3A gene. This snoRNA has no identified RNA target.
HBII-436 presents sequence similarities with SNORD119 (host gene SNRPB), which might be its ancestor.
