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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SNORD119small nucleolar RNA, C/D box 119
snoid : SR0000476
Length : 82
Abstract : Homo sapiens SNORD119 snoRNA. This C/D box snoRNA was discovered by Yang et al. (2006) with snoSeeker, and its expression verified by Northern blot. It is predicted to guide the 2'O-ribose methylation of 28S rRNA A4560. Methylation at this position was previously demonstrated. SNORD119 could be identified in the SNRBP gene in mammals, lizard, X. tropicalis and zebrafish. In opossum, two paralogues reside in a tandem duplication of the SNRBP gene. SNORD119 presents sequence similarities with HBII-436, and might be its ancestor (see alignment in HBII-436 entry). SNORD119 was independently cloned by Nahkuri et al. (2008). The size of the mature snoRNA from Northern blot is 70nt, suggesting that the terminal stem shown on the Alignment figure is trimmed during processing. These authors noted the duplication of the SNORD119 sequence in the opossum genome, and suggested that one copy is the ancestor of the HBII-52 cluster.
GenBank accession number : AM413030
Host gene : SNRPB (small nuclear ribonucleoprotein polypeptide B/B')
Click here to see the position on the UCSC Genome Browser
Target RNA : 28S rRNA A4560
References :
- Yang,J.H., Zhang,X.C., Huang,Z.P., Zhou,H., Huang,M.B., Zhang,S.,Chen,Y.Q. and Qu,L.H. (2006) snoSeeker: an advanced computational package for screening of guide and orphan snoRNA genes in the human genome. Nuc. Acids Res. 34:5112-5123
- Nahkuri, S., Taft, R. J., Korbie, D. J., and Mattick, J. S. (2008). Molecular Evolution of the HBII-52 snoRNA Cluster. J Mol Biol.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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