Homo sapiens C/D box snoRNA U45C. This snoRNA is a closely related copy of the C/D box snoRNA U45A cloned from HeLa cells by Kiss-Laszlo et al. (1996). It is predicted to guide the 2'O-ribose methylation of 18S rRNA A159. Compared to U45A, a 2 nt deletion upstream of the D' box prevents the guiding function for the methylation of 18S rRNA U172. U45C, U45A and a third paralogue,U45B, share the same host gene (RABGGTB).