Homo sapiens C/D box snoRNA U95. This snoRNA was first cloned from a rat cDNA library, and its human orthologue identified by data base search (Vitali et al., 2003). It is predicted to guide the 2'O-ribose methylation of 28S rRNA A2802 and C2811. A single copy of human U95 resides in intron 1 of the GNB2L1 gene. In the mouse, two copies reside in introns 1 and 3 of the orthologous gene. In both species, intron 2 of the same gene hosts the snoRNA U96a.