|HUGO Gene Nomenclature Committee|
|HGNC Approved Symbol||HGNC Approved Name|
|SNORA36A||small nucleolar RNA, H/ACA box 36A|
Homo sapiens ACA36 snoRNA
This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues U105 and U1244 of 18S rRNA. The pseudouridylation of U105 residue was previously reported by Maden and Wakeman (1988), but these authors could not determine whether U1243 or U1244 was modified. ACA36 and ACA56 share a common host gene (dyskerin).
A close paralogue, ACA36B (SNORA36B) resides in the RAB3-GAP150 gene. A primate-specific Type 2 snoRT (SNORA36C) resides in the AAK1 gene.|
|GenBank accession number :
|Host gene : DKC1 (dyskeratosis congenita 1, dyskerin)|
|Click here to see the position on the UCSC Genome Browser|
|Target RNA : 18S rRNA U1244 and 18S rRNA U105|
|sno/scaRNAs with same target 18S rRNA U1244 : ACA36B  SNORA36C  |
|sno/scaRNAs with same target 18S rRNA U105 : ACA8  ACA50  ACA36B  ACA62  |
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.
|snoRNABase - http://www-snorna.biotoul.fr/|