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ACA50

HUGO Gene Nomenclature Committee
HGNC Approved Symbol	HGNC Approved Name
SNORA50	small nucleolar RNA, H/ACA box 50

snoid : SR0000222

Length : 136

Abstract : Homo sapiens ACA50 snoRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residues U34 and U105 of 18S rRNA. The pseudouridylation of these residues was previously reported by Maden and Wakeman (1988). ACA50 and ACA46 share the same host gene (KIAA1007).

GenBank accession number : AJ609468

Host gene : CNOT1 (CCR4-NOT transcription complex 1)

Click here to see the position on the UCSC Genome Browser

Target RNA : 18S rRNA U34 and 18S rRNA U105

sno/scaRNAs with same target 18S rRNA U34 : ACA62

sno/scaRNAs with same target 18S rRNA U105 : ACA8 ACA36 ACA36B ACA62

References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Maden, E. H., and Wakeman, J. A. (1988). Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Biochem J 249, 459-464.

Sequence :

Phylogenic conservation: Alignment - Fasta file

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