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HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA12small Cajal body-specific RNA 12
snoid : SR0000075
Length : 270
Abstract : Homo sapiens U89 scaRNA This RNA was cloned by Darzacq et al. (2002) from HeLa cells. It is composed of an H/ACA box domain and a C/D box domain, and is associated with both fibrillarin and Gar1p. U89 co-localizes with coilin in Cajal bodies, and is predicted to guide the pseudouridylation of residue U46 in U5 snRNA (as U85). The modification of this residue was experimentally established by Krol et al. (1981).
GenBank accession number : AY077739
Host gene : REA (B-cell receptor associated protein, D-prohibitin).
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Target RNA : U5 snRNA U46
sno/scaRNAs with same target U5 snRNA U46 : U85   
References :
- Darzacq, X., Jady, B. E., Verheggen, C., Kiss, A. M., Bertrand, E., and Kiss, T. (2002). Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. Embo J 21, 2746-2756.
- Krol, A., Gallinaro, H., Lazar, E., Jacob, M., and Branlant, C. (1981). The nuclear 5S RNAs from chicken, rat and man. U5 RNAs are encoded by multiple genes. Nucleic Acids Res, 9, 769-787.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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