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ACA12
HUGO Gene Nomenclature Committee
HGNC Approved SymbolHGNC Approved Name
SCARNA23small Cajal body-specific RNA 23
snoid : SR0000367
Length : 130
Abstract : Homo sapiens ACA12 snoRNA This H/ACA box RNA was cloned by Kiss et al. (2004) from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA. The pseudouridylation of this residue was previously reported by Epstein et al. (1980). In mouse and rat genomes, ACA12 sequences that reside in the expected intron of the PolA gene appear not functional. In these species, the pseudouridylation of U6snRNA U40 might be guided by HBI-100.
GenBank accession number : AJ609482
Host gene : POLA (DNA polymerase alpha catalytic subunit ,EC 2.7.7.7).
Click here to see the position on the UCSC Genome Browser
Target RNA : U6 snRNA U40
sno/scaRNAs with same target U6 snRNA U40 : HBI-100   
References :
- Kiss, A. M., Jady, B. E., Bertrand, E., and Kiss, T. (2004). Human box H/ACA pseudouridylation guide RNA machinery. Mol. Cell .Biol. 24, 5797-5807
- Epstein, P., Reddy, R., Henning, D., and Busch, H. (1980). The nucleotide sequence of nuclear U6 (4.7 S) RNA. J Biol Chem, 255, 8901-8906.
Sequence :
Phylogenic conservation: Alignment - Fasta file
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