Homo sapiens U70 snoRNA.
This H/ACA box RNA was cloned from HeLa cells by Ganot et al. (1997b). Its role in guiding pseudouridylation of U1692 in 18S rRNA was evidenced by Ganot et al. (1997b). The pseudouridylation of this residue was confirmed by the same authors.
The U70 gene resides in the RPL10 from human to fishes, with an intragenic duplication in zebrafish.
Twelve human U70 type 3 snoRTs reside in an intron of a known gene in the sense orientation, including U70B (USP34), U70C (ASTN2), U70D (PHLPPL), U70E (RAB30), U70F (COBLL1) and U70G (RAP1B) (Weber, 2006; Luo and Li, 2007).